renal function

By Targets:	Autophagy (2) Cytochrome P450 (1) Endogenous Metabolite (5) Epoxide Hydrolase (1) HIF/HIF Prolyl-Hydroxylase (1) Isotope-Labeled Compounds (2) Mitochondrial Metabolism (4) Mitophagy (2) Phosphodiesterase (PDE) (1) PKA (1) PROTACs (1) Reactive Oxygen Species (1) TGF-beta/Smad (1) Urotensin Receptor (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (13) Inflammation/Immunology (6) Metabolic Disease (5) Neurological Disease (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147025

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine 1 Publications Verification	PROTACs TGF-beta/Smad HIF/HIF Prolyl-Hydroxylase	Inflammation/Immunology
(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual target PROTAC that can not only target to the ubiquitination and degradation of Smad3 but also improve the HIF-α protein level. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine has a multi-path anti-fibrosis function and a renal protection function for research of renal anemia .

HY-107544

8-pCPT-2'-O-Me-cAMP-AM	PKA	Metabolic Disease
8-pCPT-2'-O-Me-cAMP-AM is a cyclic AMP analogue, selectively activates Epac-Rap signaling pathway. 8-pCPT-2'-O-Me-cAMP-AM protects renal function by activating Epac from ischemia injury. 8-pCPT-2'-O-Me-cAMP-AM also stimulates insulin secretion by interaction with PKA pathway .

HY-B0932

Levocarnitine propionate hydrochloride L-Propionylcarnitine chloride; ST-261	Others	Others
Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is used to treat the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.

HY-151342

Ser@TPP@CUR	Others	Others
Ser@TPP@CUR is a Curcumin (HY-N0005) derivative. Ser@TPP@CUR effectively ameliorates injured renal tubular epithelial cells and improves renal functions of acute kidney injury (AKI) mice. Ser@TPP@CUR can be used for the research of AKI .

HY-145546

14(15)-EpETE

Cytochrome P450 Metabolic Disease

14(15)-EpETE is the epoxide of cytochrome P450 (CYP450) and is involved in the regulation of vascular tone and renal function .

14(15)-EpETE	Cytochrome P450	Metabolic Disease
14(15)-EpETE is the epoxide of cytochrome P450 (CYP450) and is involved in the regulation of vascular tone and renal function .

HY-P0125

Elamipretide MTP-131; RX-31; SS-31	Mitochondrial Metabolism	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Elamipretide (MTP-131) is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury .

HY-B0932S1

Levocarnitine propionate-d5 hydrochloride L-Propionylcarnitine-d₅ (chloride); ST-261-d₅	Isotope-Labeled Compounds	Others
Levocarnitine propionate-d₅ (hydrochloride) is the deuterium labeled Levocarnitine propionate hydrochloride. Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is used to treat the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.

HY-B0932S

Levocarnitine propionate-d3 hydrochloride L-Propionylcarnitine-d₃ (chloride); ST-261-d₃	Isotope-Labeled Compounds	Others
Levocarnitine propionate-d₃ (hydrochloride) is the deuterium labeled Levocarnitine propionate hydrochloride. Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is used to treat the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.

HY-W040821

DL-Homocysteine 2 Publications Verification	Endogenous Metabolite	Neurological Disease
DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity .

HY-114683

KS370G	Others	Cardiovascular Disease
KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy .

HY-B0594

Iohexol 2 Publications Verification	Autophagy Mitophagy	Cancer
Iohexol is a non-ionic, water-soluble contrast agent used as a reference marker for the determination of glomerular filtration rate (GFR) at the level of renal function. Iohexol can be used for contrast in myelography, computerized tomography (cisternography, ventriculography) and MicroCT imaging .

HY-14464

PF-00489791 PF-489791	Phosphodiesterase (PDE)	Metabolic Disease
PF-00489791 (PF-489791) is a potent inhibitor of phosphodiesterase 5A with IC₅₀ of 1.5 nM. PF-00489791 can enhance the relaxation of blood vessels within the kidney and so reduce blood pressure, improving renal function .

HY-10655

Palosuran 3 Publications Verification ACT-058362	Urotensin Receptor	Cardiovascular Disease
Palosuran (ACT-058362) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC₅₀ of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran can improves pancreatic and renal function in diabetic rats .

HY-10655A

Palosuran hydrochloride 3 Publications Verification ACT-058362 hydrochloride	Urotensin Receptor	Cardiovascular Disease
Palosuran hydrochloride (ACT-058362 hydrochloride) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC₅₀ of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran hydrochloride can improves pancreatic and renal function in diabetic rats .

HY-Y0271S

Urea-15N2 Carbamide-¹⁵N₂; Carbonyldiamide-¹⁵N₂	Endogenous Metabolite	Cardiovascular Disease Cancer
Urea- ¹⁵N₂ is the ¹⁵N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

HY-Y0271S1

Urea-d4 1,1,3,3-Tetradeuteriourea; Urea-d₄	Endogenous Metabolite
Urea-d₄ is the deuterium labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[2]. A potent emollient and keratolytic agent[3]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[4]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

HY-Y0271

Urea 1 Publications Verification Carbonyl diamide	Endogenous Metabolite	Cardiovascular Disease Cancer
Urea is a powerful protein denaturant via both direct and indirect mechanisms . A potent emollient and keratolytic agent . Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function . Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

HY-B0594R

Iohexol (Standard)	Autophagy Mitophagy	Cancer
Iohexol (Standard) is the analytical standard of Iohexol. This product is intended for research and analytical applications. Iohexol is a non-ionic, water-soluble contrast agent used as a reference marker for the determination of glomerular filtration rate (GFR) at the level of renal function. Iohexol can be used for contrast in myelography, computerized tomography (cisternography, ventriculography) and MicroCT imaging .

HY-134769

OPC-163493	Mitochondrial Metabolism Reactive Oxygen Species	Cardiovascular Disease Metabolic Disease
OPC-163493 is an orally active liver-targeted mitochondrial uncoupling agent. OPC-163493 reduces Δψ and mitochondrial ROS production. OPC-163493 has antidiabetic and cardiovascular beneficial effects. OPC-163493 lowers blood pressure, extends survival, and improves renal function in the rat model of stroke/hypertension .

HY-P0125B

Elamipretide triacetate Maximum Cited Publications 11 Publications Verification MTP-131 triacetate; RX-31 triacetate; SS-31 triacetate	Mitochondrial Metabolism	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Elamipretide triacetate (MTP-131 triacetate; RX-31 triacetate; SS-31 triacetate) is Elamipretide triacetate form of Elamipretide (HY-P0125). Elamipretide triacetate is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury .

HY-P0125A

Elamipretide TFA MTP-131 TFA; RX-31 TFA; SS-31 TFA	Mitochondrial Metabolism	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Elamipretide TFA (MTP-131 TFA; RX-31 TFA; SS-31 TFA) is the TFA salt form of Elamipretide (HY-P0125). Elamipretide TFA is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury .

HY-Y0271S2

Urea-13C,15N2	Endogenous Metabolite
Urea- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

HY-151616

sEH inhibitor-10	Epoxide Hydrolase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
sEH inhibitor-10 (Compound 37) is a selective soluble epoxide hydrolase (sEH) inhibitor (IC₅₀=0.5 μM). sEH inhibitor-10 maintains high cycloeicosatrienoic acid (EETs) levels by inhibiting sEH, thereby reducing inflammation, regulating endothelial tone, improving mitochondrial function, and reducing oxidative stress. sEH inhibitor-10 has good research potential in metabolic, renal and cardiovascular diseases .

Cat. No.	Product Name

HY-L051

Ferroptosis Compound Library	938 compounds
Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc. MCE carefully collected a unique collection of 938 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.

Ferroptosis Compound Library

938 compounds

Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc.

MCE carefully collected a unique collection of 938 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.

Cat. No.	Product Name	Target	Research Area

HY-P0125B

Elamipretide triacetate Maximum Cited Publications 11 Publications Verification MTP-131 triacetate; RX-31 triacetate; SS-31 triacetate	Mitochondrial Metabolism	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Elamipretide triacetate (MTP-131 triacetate; RX-31 triacetate; SS-31 triacetate) is Elamipretide triacetate form of Elamipretide (HY-P0125). Elamipretide triacetate is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury .

HY-P5978

Atriopeptin III (rat) ANP 127-150 (rat)	Peptides	Cardiovascular Disease
Atriopeptin III (ANP 127-150) (rat), a 24-amino acid atrial peptide, is a potent vasodilator and natriuretic/diuretic agent. Atriopeptin III (rat) improves renal functions and decreases blood pressure in a ureter-obstructed rat kidney model. Atriopeptin III (rat) can be used for research of chronic renal failure .

HY-P10369

Betiatide	Peptides	Cardiovascular Disease Inflammation/Immunology
Betiatide, as a chelating agent for Technetium-99m ( ^99mTc), is used to prepare ^99mTc-MAG3 (mercaptoacetyltriglycine), a radiopharmaceutical for renal function imaging. Betiatide is used for the diagnosis of congenital and acquired abnormalities, renal failure, urinary tract obstructions, and calculi .

HY-P0125

Elamipretide MTP-131; RX-31; SS-31	Mitochondrial Metabolism	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Elamipretide (MTP-131) is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury .

HY-P10279

Anaritide Human atrial natriuretic factor (102–126)	Peptides	Cardiovascular Disease Others
Anaritide is a synthetic form of atrial natriuretic peptide (ANP) composed of 25 amino acids. Anaritide increases glomerular filtration rate by dilating into and contracting out the bulbar arterioles. Anaritide can be used to study the effects on patients with acute tubular necrosis, particularly in improving dialysis free survival .

HY-P0125A

Elamipretide TFA MTP-131 TFA; RX-31 TFA; SS-31 TFA	Mitochondrial Metabolism	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Elamipretide TFA (MTP-131 TFA; RX-31 TFA; SS-31 TFA) is the TFA salt form of Elamipretide (HY-P0125). Elamipretide TFA is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury .

HY-P5490

Spexin-2 (53-70), human,mouse,rat NPQ 53-70	Peptides	Others
Spexin-2 (53-70), human,mouse,rat (NPQ 53-70) is a biological active peptide. (This is Spexin-2 (53-70), non-amidated version of the novel peptide hormone that is derived from prohormone proNPQ and is conserved amongst mammalian species. It is a central modulator of cardiovascular and renal function. Spexin-2, when administered to rats, decreases heart rate and increases urine flow rate)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W040821

DL-Homocysteine 2 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite
DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity .

HY-Y0271

Urea 1 Publications Verification Carbonyl diamide	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Endogenous Metabolite
Urea is a powerful protein denaturant via both direct and indirect mechanisms . A potent emollient and keratolytic agent . Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function . Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

Cat. No.	Product Name	Chemical Structure

HY-B0932S

Levocarnitine propionate-d3 hydrochloride
Levocarnitine propionate-d₃ (hydrochloride) is the deuterium labeled Levocarnitine propionate hydrochloride. Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is used to treat the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.

HY-Y0271S

Urea-15N2
Urea- ¹⁵N₂ is the ¹⁵N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

HY-Y0271S1

Urea-d4
Urea-d₄ is the deuterium labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[2]. A potent emollient and keratolytic agent[3]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[4]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

HY-Y0271S2

Urea-13C,15N2
Urea- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

Urea-13C,15N2

Urea- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

HY-B0932S1

Levocarnitine propionate-d5 hydrochloride
Levocarnitine propionate-d₅ (hydrochloride) is the deuterium labeled Levocarnitine propionate hydrochloride. Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is used to treat the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds